Download USMLE Step 1 Lecture Notes 2018 PDF – Kaplan Lecture Notes [Direct Link]

USMLE Step 1 Lecture Notes 2018 by Kaplan medical is most certainly the best book from the volume (of 7 books) for the preparation of medical license exam for the U.S. This book is the most comprehensive and advanced one to date for achieving high score in the exam. It has been recommended by most senior medical affiliates therefore, it is a must have book in your collection while preparing for the medical licence exam. Please find the list of all volumes below,

    • USMLE Step 1 Lecture Notes 2017 Anatomy
  • USMLE Step 1 Lecture Notes 2017 Behavioral Science and Social Sciences
  • USMLE Step 1 Lecture Notes 2017 Biochemistry and Medical Genetics
  • USMLE Step 1 Lecture Notes 2017 Pathology
  • USMLE Step 1 Lecture Notes 2017 Pharmacology
  • USMLE Step 1 Lecture Notes 2017 Physiology


    • 2700+ Pages covering every discipline
  • Full color diagrams and charts for better comprehension
  • Clinical correlations and bridges between disciplines
  • Chapter summaries for easier review
  • Clinical updates included in all 7 volumes


USMLE Step 1 Lecture Notes 2018 Anatomy

Part 1: Early Embryology and Histology: Epithelia

Chapter 1: Gonad Development
Chapter 2: First 8 Weeks of Development
Chapter 3: Histology: Epithelia

Part 2: Gross Anatomy

Chapter 1: Back and Autonomic Nervous System
Chapter 2: Thorax
Chapter 3: Abdomen, Pelvis, and Perineum
Chapter 4: Upper Limb
Chapter 5: Lower Limb
Chapter 6: Head and Neck

Part 3: Neuroscience

Chapter 1: Nervous System Organization and Development
Chapter 2: Histology of the Nervous System
Chapter 3: Ventricular System
Chapter 4: The Spinal Cord
Chapter 5: The Brain Stem
Chapter 6: The Cerebellum
Chapter 7: Basal Ganglia
Chapter 8: Visual Pathways
Chapter 9: Diencephalon
Chapter 10: Cerebral Cortex
Chapter 11: Limbic System

USMLE Step 1 Lecture Notes 2018 Behavioral Science and Social Sciences

Part 1: Epidemiology and Biostatistics

Chapter 1: Epidemiology
Chapter 2: Biostatistics

Part 2: Behavioral Science

Chapter 1: Developmental Life Cycle
Chapter 2: Theories of Learning and Behavioral Modification
Chapter 3: Defense Mechanism
Chapter 4: Psychologic Health and Testing
Chapter 5: Substance Use Disorders
Chapter 6: Sleep and Sleep Disorders
Chapter 7: Psychiatric (DSM-5) Disorders
Chapter 8: Psychopharmacology
Chapter 9: Brain Function and Neurocognitive Disorders
Chapter 10: Ethics, Law, and Physician Behavior
Chapter 11: Health Care Delivery Systems

Part 3: Social Sciences

Chapter 1: Basic Science of Patient Safety

USMLE Step 1 Lecture Notes 2018 Biochemistry and Medical Genetics

Part 1: Biochemistry

Chapter 1: Nucleic Acid Structure and Organization
Chapter 2: DNA Replication and Repair
Chapter 3: Transcription and RNA Processing
Chapter 4: The Genetic Code, Mutations, and Translation
Chapter 5: Regulation of Eukoryotic Gene Expression
Chapter 6: Genetic Strategies in Therapeutics
Chapter 7: Techniques of Genetic Analysis
Chapter 8: Amino Acids, Protein, and Enzymes
Chapter 9: Harmones
Chapter 10: Vitamins
Chapter 11: Energy Metabolism
Chapter 12: Glycolysis and Pyruvate Dehydrogenase
Chapter 13: Citric Acid Cycle and Oxidative Phosphorylation
Chapter 14: Glycogen, Gluconeogenesis, And the Hexose Monophosphate Shunt
Chapter 15: Lipid Synthesis Storage
Chapter 16: Lipid Mobilization And Catabolism
Chapter 17: Amino Acid Metabolism
Chapter 18: Purine and Pyrimidine Metabolism

Part 2: Medical Genetics

Chapter 1: Single-Gene Disorders
Chapter 2: Population Genetics
Chapter 3: Cytogenetics
Chapter 4: Genetics of Common Diseases
Chapter 5: Recombination Frequency
Chapter 6: Genetic Diagnosis

USMLE Step 1 Lecture Notes 2018 Immunology and Microbiology

Part 1: Immunology

Chapter 1: The Immune System
Chapter 2: Ontogeny of the Immune Cells
Chapter 3: Lymphocyte Development and Selection
Chapter 4: Periphery: Innate Immune Response
Chapter 5: Secondary Lymphoid Tissue: Innate Immune Response Meets Adaptive
Chapter 6: Secondary Lymphoid Tissue: B and T Lymphoid Activation
Chapter 7: Humoral Immunity
Chapter 8: Cell-Medicated Immunity
Chapter 9: Immunodiagnostics
Chapter 10: Immunizations
Chapter 11: Primary Immunodeficiencies
Chapter 12: Hypersensitivity and Autoimmune Disease
Chapter 13: Transplantation

Part 2: Microbiology

Chapter 1: General Microbiology
Chapter 2: Medically Relevant Bacteria
Chapter 3: Bacterial Genetics
Chapter 4: Medically Relevant Viruses
Chapter 5: Medically Relevant Fungi
Chapter 6: Medical Parasitology
Chapter 7: Clinical Infectious Disease
Chapter 8: Comparative Microbiology

USMLE Step 1 Lecture Notes 2018 Pathology

Chapter 1: Fundamentals of Pathology
Chapter 2: Cellular Injury And Adaptation
Chapter 3: Inflammation
Chapter 4: Tissue Repair
Chapter 5: Circulatory Pathology
Chapter 6: Genetic Disorders
Chapter 7: Immunopathology
Chapter 8: Amyloidosis
Chapter 9: Principles of Neoplasia
Chapter 10: Skin Pathology
Chapter 11: Red Blood Cell Pathology: Anemias
Chapter 12: Vascular Pathology
Chapter 13: Cardiac Pathology
Chapter 14: Respiratory Pathology
Chapter 15: Renal Pathology
Chapter 16: Gastrointestinal Tract Pathology
Chapter 17: Pancreatic Pathology
Chapter 18: Gallbladder And Biliary Tract Pathology
Chapter 19: Liver Pathology
Chapter 20: Central Nervous System Pathology
Chapter 21: Hematopoetic Pathology–White Blood Cell Disorders & Lymphoid and Myeloid Neoplasms
Chapter 22: Female Genital Pathology
Chapter 23: Breast Pathology
Chapter 24: Male Pathology
Chapter 25: Endocrine Pathology
Chapter 26: Bone Pathology
Chapter 27: Joint Pathology
Chapter 26: Skeletal Muscle and Peripheral Nerve Pathology

USMLE Step 1 Lecture Notes 2018 Pharmacology

Part 1: General Principles

Chapter 1: Pharmacokinetics
Chapter 2: Pharmacodynamics
Chapter 3: Practice Questions

Part 2: Autonomic Pharmacology

Chapter 1: The Autonomic Nervous System (ANS)
Chapter 2: Cholinergic Pharmacology
Chapter 3: Adrenergic Pharmacology
Chapter 4: Autonomic Drugs: Glaucoma Treatment and ANS Practice Problems
Chapter 5: Autonomic Drug List and Practice Questions

Part 3: Cardiac and Renal Pharmacology

Chapter 1: Diuretics
Chapter 2: Antihypertensives
Chapter 3: Drugs for Heart Failure
Chapter 4: Antiarrhythmic Drugs
Chapter 5: Antianginal Drugs
Chapter 6: Antihyperlipidemics
Chapter 7: Cardiac and Renal Drug List and Practice Questions

Part 4: CNS Pharmacology

Chapter 1: Sedative-Hypnotic-Anxiolytic Drugs
Chapter 2: Alcohols
Chapter 3: Drugs Used for Depression, Bipolar Disorders, And Attention Deficit Hyperactivity Disorder (ADHD)
Chapter 4: Drugs Used in Parkinson Disease and Psychosis
Chapter 5: Anticonvulsants
Chapter 6: Drugs Used in Anesthesia
Chapter 7: Opioid Analgesics
Chapter 8: Drugs of Abuse
Chapter 9: CNS Drug List and Practice Questions

Part 5: Antimicrobial Agents

Chapter 1: Antibacterial Agents
Chapter 2: Antifungal Agents
Chapter 3: Antiviral Agents
Chapter 4: Antiprotozoal Agents
Chapter 5: Antimicrobial Drug List and Practice Questions

Part 6: Drugs of Inflammatory and Related Disorders

Chapter 1: Histamine and Antihistamines
Chapter 2: Drugs Used in Gastrointestinal Dysfunction
Chapter 3: Drugs Acting on Serotonergic Systems
Chapter 4: Eicosanoid Pharmacology
Chapter 5: Drugs Used for Treatment of Rheumatoid Arthritis
Chapter 6: Drugs Used for Treatment of Gout
Chapter 7: Glucocorticoids
Chapter 8: Drugs Used for Treatment of Asthma
Chapter 9: Inflammatory Disorders Drug List and Practice Questions

Part 7: Drugs Used in Blood Disorders

Chapter 1: Anticoagulants
Chapter 2: Thrombolytics
Chapter 3: Antiplatelet Drugs
Chapter 4: Blood Disorder Drug List and Practice Questions

Part 8: Endocrine Pharmacology

Chapter 1: Drugs Used in Diabetes
Chapter 2: Steroid Hormones
Chapter 3: Antithyroid Agents
Chapter 4: Drugs Related to Hypothalamic and Pituitary Hormones
Chapter 5: Drugs Used for Bone and Mineral Disorders
Chapter 6: Endocrine Drug List and Practice Questions

Part 9: Anticancer Drugs

Chapter 1: Anticancer Drugs
Chapter 2: Anticancer Drug Practice Questions

Part 10: Immunopharmacology

Chapter 1: Immunopharmacology
Chapter 2: Immunopharmacology Practice Questions

Part 11: Toxicology

Chapter 1: Toxicology
Chapter 2: Toxicology Practice Questions

USMLE Step 1 Lecture Notes 2018 Physiology

Part 1: Fluid Distribution and Edema

Chapter 1: Fluid Distribution and Edema

Part 2: Excitable Tissue

Chapter 1: Ionic Equilibrium and Resting Membrane Potential
Chapter 2: The Neuron Action Potential and Synaptic Transmission
Chapter 3: Electrical Activity of the Heart

Part 3: Muscle

Chapter 1: Excitation-Contraction Coupling
Chapter 2: Skeletal Muscle Mechanics

Part 4: Cardiovascular

Chapter 1: Hemodynamics and Important Principles
Chapter 2: Cardiac Muscle Mechanics
Chapter 3: CV Regulation and Cardiac Output
Chapter 4: Regulation of Blood Flow
Chapter 5: Cardiac Cycle and Valvular Heart Disease

Part 5: Respiration

Chapter 1: Lung Mechanics
Chapter 2: Alveolar-Blood Gas Exchange
Chapter 3: Transport of O2 and CO2 and the Regulation of Ventilation
Chapter 4: Ventilation/Perfusion Matching and Hypoxemia

Part 6: Renal Physiology

Chapter 1: Renal Structure and Glomerular Filtration
Chapter 2: Solute Transport: Reabsorption and Secretion
Chapter 3: Clinical Estimation of GFR and Pattern of Clearance
Chapter 4: Regional Transport
Chapter 5: Acid-Base Regulation

Part 7: Endocrinology

Chapter 1: General Aspects of the Endocrine System
Chapter 2: Hypothalamic-Anterior Pituitary System
Chapter 3: Posterior Pituitary
Chapter 4: Adrenal Cortex
Chapter 5: Adrenal Medulla
Chapter 6: Endocrine Pancreas
Chapter 7: Hormonal Control of Calcium and Phosphate
Chapter 8: Thyroid Hormones
Chapter 9: Growth, Growth Hormone, and Puberty
Chapter 10: Male Reproductive System
Chapter 11: Female Reproductive System

Part 8: Gastrointestinal Physiology

Chapter 1: Overview of Motility
Chapter 2: Secretions
Chapter 3: Digestion and Absorption


Dr. Taimour is a dedicated medical professional and passionate advocate for international medical graduates seeking to pursue their dream of becoming a doctor abroad. With a wealth of experience and firsthand knowledge of the challenges and rewards of this journey, Dr. Harrison is committed to helping aspiring physicians navigate the complex world of medical licensure exams, such as the USMLE and PLAB, and find their path to success in foreign medical practice.

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