The goal of Pathophysiology of Disease: An Introduction to Clinical Medicine—as outlined in the introductory chapter (Chapter 1)—is to introduce students to clinical medicine by reviewing the pathophysiologic basis of the symptoms and signs of various common diseases. Th e book has proved useful as a text for both Pathophysiology and Introduction to Clinical Medicine courses in medical schools, and it has been popular in similar courses in nursing schools, physicians’ assistant training programs, and other allied health programs. It is valuable to students early in their medical school years by highlighting the clinical relevance of their basic science courses, and in preparation for their USMLE Step 1 examinations. Th e book is also helpful to students engaged in their internal medicine and surgery clerkships, and to house officers as an up-to-date summary of relevant physiology and a source of key references. Practitioners (both general internists and specialists who provide generalist care) will find it beneficial as a refresher text, designed to update their knowledge of the mechanisms underlying 120 commonly encountered diseases. Nurses, nurse-practitioners, physicians’ assistants and other allied health practitioners have found that its concise format and broad scope facilitate their understanding of these basic disease entries. Pathophysiology of Disease has been widely adopted in the United States, Canada, and the United Kingdom, and it has been translated into Spanish, Italian, Chinese, Japanese, Greek and Turkish. Both the text and its Case Studies Questions and Answers are also available on the Internet, at www.accessmedicine. com, an online version of McGraw-Hill’s many medical textbooks. New Features for This Edition In preparation for this seventh edition, the editors and authors reviewed the entire book. Th ere have been many revisions aimed at updating information, improving clarity, and eliminating minor errors. References have also been updated, with emphasis on valuable reviews. “Checkpoints,” collections of review questions, which continue to appear throughout the chapters, have been revised. Examples of New Content Found in Th is Edition
• Expanded sections on recent advances in whole genome sequencing approaches
• Update on the molecular biology of cells of the immune system and infl ammatory mediators
• Update on role of thrombopoietin in thrombopoiesis
• Substantial revision of coagulation factors and the coagulation system, including a new figure summarizing the coagulation cascade
• Update on pathogenesis of immune-mediated and heparininduced thrombocytopenia
• Revised sections on the pathogenesis of psoriasis, erythema multiforme and bullous pemphigoid
• Revised sections on the pathophysiology of idiopathic pulmonary fi brosis and pulmonary edema
• Updated section on endothelin physiology and pathophysiology
• Revised sections on adaptive and innate immunity of the gastrointestinal tract

The goal of Pathophysiology of Disease: An Introduction to Clinical Medicine, as outlined in the introductory chapter (Chapter 1), is to introduce students to clinical medicine by reviewing the pathophysiologic basis of the symptoms and signs of various common diseases. The book has proved useful as a text for both Pathophysiology and Introduction to Clinical Medicine courses in medical schools, and it has been popular in similar courses in nursing schools, physician assistants’ training programs, and other allied health programs. It is valuable to students early in their medical school years by highlighting the clinical relevance of their basic science courses, and in preparation for their USMLE Step 1 examinations. The book is also helpful to students engaged in their internal medicine and surgery clerkships, and to house officers as an up-to-date summary of relevant physiology and a source of key references. Practitioners (both general internists and specialists who provide generalist care) will find it beneficial as a refresher text, designed to update their knowledge of the mechanisms underlying 132 commonly encountered diseases and disorders. Nurses, nurse-practitioners, physician assistants, and other allied health practitioners have found that its concise format and broad scope facilitate their understanding of these basic disease entities. Pathophysiology of Disease has been widely adopted in the United States, Canada, and the United Kingdom, and it has been translated into Spanish, Italian, Chinese, Japanese, Greek, and Turkish. Both the text and its Case Study Questions and Answers are also available online at accessmedicine.mhmedical.com, the online version of McGraw-Hill’s many medical textbooks (search under “Books, Library, Basic Science” for “Pathophysiology,” listed alphabetically).