There have been remarkable advances in the understanding of the pathogenesis of diseases of the blood and lymphatic system and in the treatment of these diseases, since the 6th Edition of Essential Haematology was published in 2011. This new knowledge is due largely to the application of next generation sequencing of DNA which has enabled the detection of the genetic mutations, inherited or acquired, that underlie these diseases. As examples, sequencing has revealed the CALR mutation underlying a substantial proportion of patients with myeloproliferative diseases and the MYD88 mutation present in almost all cases of Waldenström’s macrogobulinaemia. Multiple ‘driver’ gene mutations affecting signalling pathways and epigenetic reactions involved in cell proliferation and survival have been discovered which underlie myelodysplasia, acute myeloid and lymphoblastic leukaemias, chronic lymphocytic leukaemia and the lymphomas. The complexity of the molecular changes underlying the malignant diseases and the relevance of this to their sensitivity or resistance to therapy is becoming apparent. This new knowledge has been accompanied by spectacular improvements in therapy. Inhibition of the B cell receptor signalling pathway has transformed the life expectancy in many patients with resistant chronic lymphocytic leukaemia and some of the B cell lymphomas resistant to other therapy. JAK2 inhibitors are improving the quality of life and survival in primary myelofibrosis. Survival in myeloma is improving remarkably with new proteasome inhibitory and immunomodulatory drugs. Life expectancy has also improved for patients with diseases such as thalassaemia major receiving multiple transfusions with the worldwide introduction of orally active iron chelating agents. New anticoagulants which directly inhibit at a single point in the coagulation cascade and rarely need monitoring are now used commonly in preference to warfarin for the treatment and prevention of arterial and venous thrombosis. These advances in knowledge have been incorporated as new text, diagrams and tables for this seventh edition. New multiple choice questions have been added to the website and short summary boxes are included at the end of each chapter

There have been remarkable advances in the understanding of the pathogenesis of diseases of the blood and lymphatic system and in the treatment of these diseases, since the 6th Edition of Essential Haematology was published in 2011. This new knowledge is due largely to the application of next generation sequencing of DNA which has enabled the detection of the genetic mutations, inherited or acquired, that underlie these diseases. As examples, sequencing has revealed the CALR mutation underlying a substantial proportion of patients with myeloproliferative diseases and the MYD88 mutation present in almost all cases of Waldenström’s macrogobulinaemia. Multiple ‘driver’ gene mutations affecting signalling pathways and epigenetic reactions involved in cell proliferation and survival have been discovered which underlie myelodysplasia, acute myeloid and lymphoblastic leukaemias, chronic lymphocytic leukaemia and the lymphomas. The complexity of the molecular changes underlying the malignant diseases and the relevance of this to their sensitivity or resistance to therapy is becoming apparent. This new knowledge has been accompanied by spectacular improvements in therapy. Inhibition of the B cell receptor signalling pathway has transformed the life expectancy in many patients with resistant chronic lymphocytic leukaemia and some of the B cell lymphomas resistant to other therapy. JAK2 inhibitors are improving the quality of life and survival in primary myelofibrosis. Survival in myeloma is improving remarkably with new proteasome inhibitory and immunomodulatory drugs. Life expectancy has also improved for patients with diseases such as thalassaemia major receiving multiple transfusions with the worldwide introduction of orally active iron chelating agents. New anticoagulants which directly inhibit at a single point in the coagulation cascade and rarely need monitoring are now used commonly in preference to warfarin for the treatment and prevention of arterial and venous thrombosis. These advances in knowledge have been incorporated as new text, diagrams and tables for this seventh edition. New multiple choice questions have been added to the website and short summary boxes are included at the end of each chapter

Now in its 13th edition, Junqueira’s Basic Histology continues as the preeminent source of concise yet thorough information on human tissue structure and function. For over 40 years this educational resource has met the needs of learners for a well-organized and concise presentation of cell biology and histology that integrates the material with that of biochemistry and physiology and provides an excellent foundation for subsequent studies in pathology. The text is prepared specifically for students of medicine and other health-related professions, as well as for advanced undergraduate courses in tissue biology. As a result of its value and appeal to students and instructors alike, Junqueira’s Basic Histology is used worldwide in nearly a dozen different languages. For this edition I have revised the text and shortened each chapter while adding new information and expanding coverage of specific topics as needed. Study is also facilitated by a new style and page design. Inserted throughout each chapter are more numerous, short paragraphs that indicate how the information presented can be used medically and which emphasize the foundational relevance of the material learned. Prompted by student requests, I also now close each chapter with a list of the key points summarizing that chapter. More figures and summary tables organizing the information to facilitate student learning have also been added to each chapter. Additional new art and other figures are present in each chapter, with the goal to simplify learning and integration with related material. The McGraw-Hill medical illustrations now used throughout the text, supplemented by numerous animations in the electronic version of the text, are the most useful, thorough, and attractive of any similar medical textbook. Electron and light micrographs have been replaced throughout the book as needed, and again they make up a complete atlas of cell, tissue, and organ structures fully compatible with the students’ own collection of glass or digital slides. A virtual microscope with over 150 slides of all human tissues and organs is available: http://medsci.indiana.edu/ junqueira/virtual/junqueira.htm. As with the previous edition, the book facilitates learning by its organization:
■ An opening chapter reviews how the structures of cells and tissues are studied.
■ Two chapters then summarize the structural and functional organization of the human cell cytoplasm and nucleus.
■ The next seven chapters cover the four basic tissues that make up our organs: epithelia, connective tissue (and its major subtypes), nervous tissue, and muscle.
■ Remaining chapters explain the organization and functional significance of these tissues in each of the body’s organ system, closing with up-to-date consideration of cells in the eye and ear. For student review and rapid assimilation of the material in Junqueira’s Basic Histology, McGraw-Hill has published a set of 200 full-color Basic Histology Flash Cards, both as actual cards and as an app for smart phone, tablet, or computer use, with each card having key structures to identify a summary of important facts and a clinical comment. With these new features, I am confident that Junqueira’s Basic Histology will continue as one of the most useful and widely used educational resources in histology.

With this 15th edition, Junqueira’s Basic Histology continues as the preeminent source of concise yet thorough information on human tissue structure and function. For over 45 years this educational resource has met the needs of learners for a well-organized and concise presentation of cell biology and histology that integrates the material with that of biochemistry, immunology, endocrinology, and physiology and provides an excellent foundation for subsequent studies in pathology. The text is prepared specifically for students of medicine and other health-related professions, as well as for advanced undergraduate courses in tissue biology. As a result of its value and appeal to students and instructors alike, Junqueira’s Basic Histology has been translated into a dozen different languages and is used by medical students throughout the world. Unlike other histology texts and atlases, the present work again includes with each chapter a set of multiple-choice Self-Test Questions that allow readers to assess their comprehension and knowledge of important points in that chapter. At least a few questions in each set utilize clinical vignettes or cases to provide context for framing the medical relevance of concepts in basic science, as recommended by the US National Board of Medical Examiners. As with the last edition, each chapter also includes a Summary of Key Points designed to guide the students concerning what is clearly important and what is less so. Summary Tables in each chapter organize and condense important information, further facilitating efficient learning. Each chapter has been revised and shortened, while coverage of specific topics has been expanded and updated as needed. Study is facilitated by modern page design. Inserted throughout each chapter are more numerous, short paragraphs that indicate how the information presented can be used medically and which emphasize the foundational relevance of the material learned. The art and other figures are presented in each chapter, with the goal to simplify learning and integration with related material. The McGraw-Hill medical illustrations, now used throughout the text, are the most useful, thorough, and attractive of any similar medical textbook. Electron and light micrographs have been replaced throughout the book as needed, and they again make up a complete atlas of cell, tissue, and organ structures fully compatible with the students’ own collection of glass or digital slides. Health science students whose medical library offers AccessMedicine among its electronic resources (which includes more than 95% of U.S. medical schools) can access a complete human histology Laboratory Guide linked to the virtual microscope at the URL given below. This digital Laboratory Guide, which is new with this edition of the text and unique among learning resources offered by any histology text and atlas, provides both links to the appropriate microscope slides needed for each topic and links to the correlated figures or tables in the text. Those without AccessMedicine will lack the digital Laboratory Guide, but may still study and utilize the 150 virtual microscope slides of all human tissues and organs, which are available at: http://medsci.indiana.edu/junqueira/virtual/junqueira.htm.